Table 1.
Inhibition of vaccinia virus replication by compounds in vitro.
| Compound | IC50a | CC50b (μM) | Selectivity indexc |
|---|---|---|---|
| Nigericin | 7.9 ± 0.5 nM (Cop) | 8.2 ± 1.8 | 1038 (Cop) |
| 19.5 ± 5.7 nM (WR) | 421 (WR) | ||
| Monensin | 21.6 ± 4.4 nM | 23.0 ± 2.9 | 1065 |
| Concanamycin A | 1.7 ± 0.2 nM | 13.5 ± 5.7 | 7941 |
| Concanamycin B | 11.0 ± 1.9 nM | 21.4 ± 0.6 | 1945 |
| Concanamycin C | 2.8 ± 0.8 nM | 15.6 ± 3.2 | 5571 |
| Cidofovir | 110 ± 15 μM | >1000 | – |
| ST-246 | 9.4 ± 2.4 nM | >1000 | – |
All results are the mean ± one standard deviation of three independent experiments.
a
IC50 values were determined by plaque reduction assays in HeLa cells.
b
CC50 values were determined on cell monolayers using the WST-1 cell viability assay.
c
The selectivity index was calculated as the CC50 divided by the IC50.