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. 2022 Sep 21;13:984019. doi: 10.3389/fmicb.2022.984019

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Copyright © 2022 Luo, Yang, Pang, Zhao, Li, Rong and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The genus Lactobacillus mediated generation of 5-MIAA was capable of activating hepatic Nrf2 signaling. (A,B) Analysis of the different relative abundances of the bacterial community at the family and genus levels in HFD, TH, and HFD + FMT(TH) groups. (C) The correlations between the relative abundance of the main genus of the bacterial community and the top 30 metabolites in the HFD and FMT (TH) groups. (D–G) Content of 5-MIAA analyzed by UPLC-MS/MS in the fermentation broth of CON, HFD, CON + LGG, and HFD + LGG groups. (H–J) Relative mRNA expression of the GCLC, NQO1, and TXR1 of HepG2 cells treated with 5-MIAA. (K) Western blot analyses of Nrf2 in HepG2 cells treated with 5MIAA. All the data were presented as the means ± SD from n = 6 mice per group. Significant differences compared with the CON group were indicated by asterisks: *P < 0.05, **P < 0.01, and ***P < 0.001.