Table 1.
Expression of Slfn sequences in mouse.
| Sequence | Expression in immunity-related tissues | Expression in other or mixed tissues |
|---|---|---|
| Slfn1 | Hematopoietic stem cells, thymus, spleen, T-cells, bone marrow, lymph nodes, macrophages | Adipose tissue, aorta and veins, spinal cord |
| Slfn2 | Thymus, spleen, CD11 +ve dendritic cells, hematopoietic stem cells, macrophages | Tumors, mammary gland, lung, 19.5 dpc fetus, joints, synovial fibroblasts, inner ear, taste buds |
| Slfn3 | Thymus, CD11 +ve dendritic cells, spleen | Testis, melanoma/melanocyte cells |
| Slfn4 | Spleen, bone, lymph nodes, hematopoietic stem cells | Vagina, embryo, mammary and lung tumors, taste buds unfertilized eggs, 8-cell embryos |
| Slfn5 | Thymus, spleen, activated macrophages, bone | Lung, kidney, embryonic Rathke's pouches, testis |
| Slfn8 | Macrophages, CD11 +ve dendritic cells, spleen | Kidney |
| Slfn9 | Hematopoietic stem cells, activated macrophage, bone | Embryonic nasal region, tumors, prostate, eye, 6.5-dpc to 14-dpc embryos, mammary gland, ES cells |
| Slfn10 | Activated macrophage, thymus, hematopoietic stem cells | Pancreatic islet, lung, mammary tumor |
| 83067775–83068818 (within LOC435271) | CD11 +ve dendritic cells, | |
| Slfn14, 1st exon | Spleen |
Summary of the expression results obtained by BLAST search of NCBI databases (Appendix C). No transcripts were found for the rest of the Slfn14 predicted exons as well as for Slfn sequences in mouse m37 chromosome 11 positions 83,073,547–83,074,000 and 83,078,898–83,079,059 (Fig. 1 and Appendix A). In the latter case, the reading frame was disrupted.