Fig. 2.

Co-administration of BCV and Dryvax does not diminish the antibody response against a lethal ECTV challenge in mice. A-strain mice were vaccinated with decreasing concentrations (from neat to 1:625 dilution) of Dryvax vaccine at Day 0 and treated by oral gavage with 10 mg/kg of BCV on day 0 followed by 2.5 mg/kg treatments on Day 2, 4, 6, 8, 10, 12, and 14. Prior to challenge, blood was obtained from each animal to perform an ELISA. At Day 50 (day 0 rtc) mice were challenged with 20 PFU (10× LD₅₀) of ECTV via the IN route. Neat dilutions of Dryvax are shown. Representative experiment of N = 2 with 10 mice/group. Error bars indicate SEM.