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TABLE 4.

Induction by DNA damage of genes being studied in M. tuberculosis compared with E. coli

Gene M. tuberculosis LexA bindinga Induction ratio at 24 h in M. tuberculosis Inducible in E. coli
recA + 12.2 Yes
lexA + 9.5 Yes
ruvA + 11.1 Yes
ruvC + 7.5 No
uvrA 2.9 Yes
ssb 6.1 Yes
dnaB + 4.9 Yes
recN 1.0 Yes
dinP 1.3 Yes
dinG 1.5 Yes
recC 0.8 No
a

LexA binds to at least one of the sites tested from within the 500-bp upstream of the initiation codon (Table 5 and Fig. 3).