Table 3.

Studies of smallpox vaccine LC16m8 in immunodeficient animals.

Study	Kidokoro [3]	Yokote [14]			Gordon [13]
Immunodeficient animal	SCID mouse	Suckling mouse	SCID mouse	Cyclosporin-A treated mouse	T-cell, B-cell depleted rhesus macaque
Vaccine	LC16m8, LC16m8 derivatives, Dryvax, MVA	LC16m8, LC16mO, Lister	LC16m8, LC16mO, Lister	LC16m8, Lister	LC16m8, Dryvax
Administration route	Intraperitoneal	Intracerebral	Intraperitoneal	Intraperitoneal	Scarification
Administration dose (PFU)	103–107	103.3–105.3 (LC16m8), 101.3–103.3 (LC16mO, Lister)	105.3	107	2.5 × 105

Immunodeficient animal studies are summarized based on data from references [3], [13], [14].

SCID mouse, severe combined immunodeficient mouse; MVA, Modified vaccinia Ankara; PFU, plaque forming unit.