Fig. 4.

Effects on weight loss and protective efficacy against VV_IHD-Jchallenge induced by the different immunization regimens. All of the mice challenged with VV_IHD-J were monitored daily for the post-challenge (p.c.) percentage weight loss (A) and survival (B). (A) Data are means of percentage weight loss of each group. Mice progressively lost weight until day 4 p.c., as 25%–30%. There were no relevant differences among most of the groups, but G4 mice and one mouse of G2 started to regain weight after days 3 and 5 p.c., respectively. (B) All of the G4 mice and one mouse of G2 were protected and survived, whereas the remaining mice of G2, G3, and G5 died from days 5–14 p.c. All of the control G1 mice died on days 4 or 5 p.c.