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. Author manuscript; available in PMC: 2022 Oct 5.
Published in final edited form as: Cell Rep. 2022 Sep 20;40(12):111400. doi: 10.1016/j.celrep.2022.111400

Figure 4. Differentially bound distal enhancers associated with heart failure-specific gene expression changes.

Figure 4.

(A) Co-occurrence of increased expression of SMOC2 (by RNA-seq) and increased H3K27ac at a nearby enhancer (by ChIP-seq) in DCM. Shown are data from a representative healthy (H1) and DCM (D1) sample.

(B) Distal ChIP-seq peaks relative to their distance from transcription start sites (TSS) of genes upregulated in DCM, divided into 100-kb bins. Purple: distal peaks upregulated in DCM. Gray: An equal-size, random subset of regions matched to all heart ChIP-seq peaks was assessed. The average across 200 sets of randomized control elements is shown.

(C) Same analysis as in (B), but for genes with decreased expression in DCM and distal peaks downregulated in DCM (red). An equal-size, random subset of regions matched to all heart ChIP-seq peaks was assessed (gray).

(D and E) Transcription factor binding sites enriched in peaks upregulated (D) and downregulated (E) in DCM (Heinz et al., 2010). p values by HOMER.