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. 2022 Jun 28;127:101–110. doi: 10.1016/j.jhin.2022.06.012

Table II.

Efficacy of solutions or products based on various biocidal agents against vaccinia viruses on artificially contaminated surfaces

Biocidal agent(s) Concentration Applied volume Test strain Type of carrier Type of organic soil Temperature Exposure time Log10 Reference
Ethanol 70% # 50 μL Laboratory strain Stainless steel Dirty conditions 20°C 1 min
10 min		 4.5
>5.0		 [32]
[32]
70% # 100 μL MVA Stainless steel Clean conditions RT 1 h 5.8 [24]
Glutaraldehyde 2% #
2% ## 		50 μL Laboratory strain Stainless steel Dirty conditions 20°C 10 min
10 min		 >5.0
>5.0		 [32]
[32]
Orthophthalaldehyde 0.55% #
0.55% ## 		50 μL Laboratory strain Stainless steel Dirty conditions 20°C 5 min
5 min		 >5.0
>5.0		 [32]
[32]
Hydrogen peroxide 7.5% # 50 μL Laboratory strain Stainless steel Dirty conditions 20°C 10 min
20 min		 4.9
>5.0		 [32]
Peracetic acid 0.2% #
0.2% ## 		50 μL Laboratory strain Stainless steel Dirty conditions 20°C 10 min
10 min		 >5.0
>5.0		 [32]
[32]
Sodium hypochlorite 2.5% #
0.25% # 		50 μL Laboratory strain Stainless steel Dirty conditions 20°C 1 min
1 min		 >4.6
>4.6		 [32]
[32]
Benzyldimethyltetradecylammonium chloride 0.05% # 50 μL Laboratory strain Stainless steel Dirty conditions 20°C 1 min
10 min		 2.8
3.2		 [32]
[32]
Glucoprotamin 0.065% ## 100 μL Strain Elstree Stainless steel Clean conditions RT 5 min
15 min
30 min		 1.4
1.6
2.3		 [31]
100 μL Strain Elstree Glass Clean conditions RT 5 min
15 min
30 min		 1.2
1.5
1.7		 [31]
100 μL Strain Elstree PVC Clean conditions RT 5 min
15 min
30 min		 1.1
1.3
2.1		 [31]
Glucoprotamin 0.13% ## 100 μL Strain Elstree Stainless steel Clean conditions RT 5 min
15 min
30 min		 1.8
1.7
2.3		 [31]
100 μL Strain Elstree Glass Clean conditions RT 5 min
15 min
30 min		 1.6
1.5
2.2		 [31]
100 μL Strain Elstree PVC Clean conditions RT 5 min
15 min
30 min		 1.6
1.6
2.4		 [31]
Glucoprotamin 0.26% ## 100 μL Strain Elstree Stainless steel Clean conditions RT 5 min
15 min
30 min		 2.0
2.1
2.3		 [31]
100 μL Strain Elstree Glass Clean conditions RT 5 min
15 min
30 min		 1.9
2.3
2.3		 [31]
100 μL Strain Elstree PVC Clean Conditions RT 5 min
15 min
30 min		 2.1
2.1
2.7		 [31]
Probiotic cleaner 10% ##
2% ##
1% ##
1% ## 		100 μL MVA Stainless steel Clean conditions RT 1 h
1 h
1 h
2h		 5.8
5.8
2.8
5.8		 [24]
Alkaline cleaner 0.9% ## 50 μL Laboratory strain Stainless steel Dirty conditions 20°C 10 min >5.0 [32]

MVA, modified vaccinia virus Ankara; RT, room temperature.

dirty conditions = 0.3% sheep erythrocytes and 0.3% bovine serum albumin; clean conditions = 0.03% bovine serum albumin.

#

Solution of biocidal agent.

##

Formulated product.