Table III.
Efficacy of solutions based on glutaraldehyde against vaccinia viruses in suspension tests
| Biocidal agent | Concentration | Test strain | Exposure time | Type of organic soil | Temperature | Log10 | Reference |
|---|---|---|---|---|---|---|---|
| Glutaraldehyde | 0.5% | ATCC CRL-1549 MVA |
30 s 2 min 5 min 30 s 2 min 5 min |
10% FCS 10% FCS 10% FCS 10% FCS 10% FCS 10% FCS |
20°C 20°C 20°C 20°C 20°C 20°C |
≥2.8 ∗ ≥2.8 ∗ ≥2.8 ∗ ≥3.1 ∗ ≥3.1 ∗ ≥3.1 ∗ |
[18] [18] [18] [18] [18] [18] |
| 0.1% | ATCC CRL-1549 MVA |
30 s 2 min 5 min 30 s 2 min 5 min |
10% FCS 10% FCS 10% FCS 10% FCS 10% FCS 10% FCS |
20°C 20°C 20°C 20°C 20°C 20°C |
2.1 to ≥3.9 ∗ ≥3.8 ∗ ≥3.8 ∗ 0.7 to ≥3.1 ∗ ≥3.1 ∗ ≥3.1 ∗ |
[18] [18] [18] [18] [18] [18] |
|
| 0.05% | ATCC CRL-1549 MVA |
30 s 2 min 5 min 30 s 2 min 5 min |
10% FCS 10% FCS 10% FCS 10% FCS 10% FCS 10% FCS |
20°C 20°C 20°C 20°C 20°C 20°C |
0.5 to ≥3.9 ∗ 3.9 to ≥4.4 ∗ ≥4.6 0.2–1.9 2.1 to ≥3.9 ∗ ≥3.1 ∗ |
[18] [18] [18] [18] [18] [18] |
|
| 0.02% | Vaccination strain | 10 min | None | RT | ≥4.0 | [16] |
FCS, foetal calf serum; MVA, modified vaccinia virus Ankara; RT, room temperature.
∗
Limit of detection <4.0 log10 in some experiments.