Table I.
Demographic and clinical characteristics in children with asthma, in the global population and in patients with impaired (<65% of predicted) or normal FEF25-75.
| Total N = 381 |
Impaired N = 72 |
Normal N = 309 |
Univariate* | Multivariate** | ||
|---|---|---|---|---|---|---|
| Sex | Females | 122 (32.0) | 21 (29.2) | 101 (32.7) | 0.56 | |
| Males | 259 (68.0) | 51 (70.8) | 208 (67.3) | |||
| Age, years | 11.6 ± 2.94 | 11.5 ± 2.67 | 11.7 ± 3.01 | 0.58 | ||
| BMI (kg/m^2) | 19.9 ± 4.07 | 19.2 ± 3.55 | 20.1 ± 4.18 | 0.10 | ||
| FEV1 (% of predicted) | 96.0 (51.0 - 142.0) | 80.0 (61.0 - 105.0) | 99.0 (51.0 - 142.0) | < 0.001 | ||
| Bronchial Obstruction | FEV1 (≥ 80%) | 335 (87.9) | 38 (52.8) | 297 (96.1) | < 0.001 | |
| FEV1 (< 80%) | 46 (12.1) | 34 (47.2) | 12 (3.9) | |||
| FVC (% of predicted) | 98.0 (60.0 - 141.0) | 93.0 (70.0 - 124.0) | 99.1 (60.0 - 141.0) | < 0.001 | 1.11 (1.07 - 1.15), <0.001 | |
| FEV1/FVC | 98.9 (71.2 - 122.1) | 88.0 (71.2 - 104.2) | 101.0 (76.6 - 122.1) | < 0.001 | 1.32 (1.24 - 1.42), <0.001 | |
| FEF25-75 (% of predicted) | 86.0 (1.8 - 166.0) | 50.5 (1.8 - 64.5) | 92.0 (65.0 - 166.0) | |||
| Type-2 phenotype | No | 19 (5.0) | 5 (7.0) | 14 (4.5) | 0.39 | |
| Yes | 360 (95.0) | 66 (93.0) | 294 (95.5) | |||
| Asthma control (GINA) | Well-controlled | 215 (56.4) | 34 (47.2) | 181 (58.6) | 0.002 | |
| Partly controlled | 121 (31.8) | 21 (29.2) | 100 (32.4) | |||
| Uncontrolled | 45 (11.8) | 17 (23.6) | 28 (9.1) | |||
| Childhood Asthma Control Test (adjusted age) | 21.2 ± 4.10 | 20.0 ± 4.93 | 21.5 ± 3.84 | 0.06 | ||
Impaired: FEF25_75 <65%; Normal: FEF25_75 ≥65%
* p value
** OR (95% CI), p value