Table 4:
Associations of NFL concentrations with NIHSS at initial evaluation and at blood draw in patients with ICH from the validation cohorts
| Association between NFL and NIHSS at initial evaluation | Association between NFL and NIHSS at blood draw | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Unadjusted analysis | Multivariable analysis1 | Unadjusted analysis | Multivariable analysis1 | |||||
| Group | β (95% CI) | P-value | β (95% CI) | P-value | β (95% CI) | P-value | β (95% CI) | P-value | |
| Yale ICH study series | 96 | 0.51 (0.28, 0.73) | <0.001 | 0.52 (0.29, 0.75) | <0.001 | 0.55 (0.28, 0.82) | <0.001 | 0.58 (0.28, 0.89) | <0.001 |
| UPenn ICH study series | |||||||||
| 0–12 hours from stroke to blood draw | 36 | 0.34 (0.05, 0.63) | 0.030 | 0.32 (−0.01, 0.65) | 0.066 | N/A | N/A | N/A | N/A |
| 12–36 hours from stroke to blood draw | 40 | 0.42 (0.20, 0.64) | <0.001 | 0.42 (0.18, 0.65) | 0.001 | N/A | N/A | N/A | N/A |
| 60–84 hours from stroke to blood draw | 29 | 0.57 (0.24, 0.91) | 0.003 | 0.49 (0.12, 0.85) | 0.016 | N/A | N/A | N/A | N/A |
β=regression coefficient; CI=confidence interval; β values, 95% CIs, and p-values result from linear regression models. β values are interpreted as the change in mean NIHSS (on the square root scale) for each doubling in NFL concentration.
Multivariable models were adjusted for age, sex, hypertension, diabetes, and BMI for the Yale ICH study series, and for age, sex, hypertension, and diabetes for the longitudinal UPenn ICH series. P-values < 0.0125 are considered statistically significant after correcting for multiple testing. Information was unavailable regarding NIHSS at initial evaluation (24 from the Yale ICH study series) and NIHSS at blood draw (41 from the Yale ICH study series).