. Author manuscript; available in PMC: 2022 Oct 5.

Published in final edited form as: Sci Transl Med. 2020 Nov 11;12(569):eaay1913. doi: 10.1126/scitranslmed.aay1913

Table 5:

Associations of NFL concentrations with mRS at 3 months and 6 months after stroke in patients with ICH from the validation cohorts

		Association between NFL and mRS >3 at 3 months after stroke				Association between NFL and mRS >3 at 6 months after stroke
	N	Unadjusted analysis		Multivariable analysis¹		Unadjusted analysis		Multivariable analysis¹
Group		OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
Yale ICH study series	96	1.45 (1.07, 2.02)	0.020	1.45 (1.04, 2.08)	0.034	2.23 (1.53, 3.46)	<0.001	2.24 (1.51, 3.59)	<0.001
UPenn ICH study series
0–12 hours from stroke to blood draw	36	1.96 (1.15, 4.14)	0.032	2.22 (1.23, 4.90)	0.020	N/A	N/A	N/A	N/A
12–36 hours from stroke to blood draw	40	3.32 (1.68, 9.14)	0.005	4.14 (1.84, 13.95)	0.005	N/A	N/A	N/A	N/A
60–84 hours from stroke to blood draw	29	4.23 (1.61, 19.22)	0.017	N/A	N/A	N/A	N/A	N/A	N/A

OR=odds ratio; CI=confidence interval; ORs, 95% CIs, and p-values result from binary logistic regression models. ORs are interpreted as the multiplicative increase in the odds of a mRS > 3 for each doubling in NFL concentration.

Multivariable models were adjusted for age, sex, hypertension, diabetes, and BMI for the Yale ICH study series, and for age and sex for the longitudinal ICH series (note that multivariable analysis was not possible for the 60–84 hours from stroke to blood draw group due to its small sample size). P-values < 0.0125 are considered statistically significant after correcting for multiple testing. Information was unavailable regarding mRS at 6 months (4 from the Yale ICH study series).