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. 2022 Sep 21;13:996026. doi: 10.3389/fimmu.2022.996026

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Copyright © 2022 Xie, Gui, Deng, Chen, Chen, Liu, Ku, Tan, Huang, He, Zhang, Lewis, Chen, Xu, Xu, Huang, Liao, Zhang, An and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LAIR1 blockade reduces MDA-MB-231 tumor cell metastasis and prolongs survival in human cord blood CD34⁺ cell-reconstituted humanized mice. (A) Survival curve of mice treated by h219-LLG or control antibodies (n=9). (B) The pictures of livers from mice. Arrows indicate nodules formed by metastasized tumor cells. (C, D) The liver weight (C) and the number of surface nodules on livers (D). (E, F) H&E staining of the tumor nodules in livers. (G, H) The percentages of tumor infiltrated hCD45 cells (G), T cells (H left) and Treg cells (H right) as determined by flow cytometry. (I) The percentages of M-MDSCs in bone marrow as determined by flow cytometry. As Statistical Analysis in Methods stated: * indicates p < 0.05; ** indicates p < 0.01.