FIGURE 1.

The Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) ratings for each item in this cohort of children with Leigh syndrome. The percentages of children with Leigh syndrome were rated as normal (green), mild (yellow), moderate (amber), and severe (red) in selected items of the NPMDS. Baseline and follow‐up NPMDS scores were arranged alongside each other for comparisons in respective items: (A) current function, (B) system‐specific involvement, and (C) clinical assessment. *p < 0.05, **p < 0.01, ***p < 0.001. [Color figure can be viewed at www.annalsofneurology.org]