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Overview of major signaling pathways that regulate CSCs. Among an array of signaling pathways aberrantly activated in cancer Wnt, JAK/STAT, PI3k/Akt/mTOR, Notch, NF‐κB, Hedgehog, and TGF‐β/Smad pathways are crucial for the self‐renewal, cell growth, metastasis of CSCs, and angiogenesis. (Figures built with biorender.com)
