Table 2. Solicited local and systemic AEs by worst severity grade by dose; full analysis set.

	Grade	Ad26.F	MVA	MVAa	Ad26.Z	Placebo
N	-	48	45	11	15	23
Local AEs
Any event, n (%)	Any	38 (79.2)	40 (88.9)	5 (45.5)	13 (86.7)	4 (17.4)
	Grade 3	2 (4.2)	0	0	2 (13.3)	0
Erythema/ Redness	Any	5 (10.4)	0	0	0	0
	Grade 3	1 (2.1)	0	0	0	0
Itching	Any	8 (16.7)	4 (8.9)	1 (9.1)	1 (6.7)	0
	Grade 3	0	0	0	0	0
Pain/Tenderness	Any	38 (79.2)	40 (88.9)	4 (36.4)	13 (86.7)	4 (17.4)
	Grade 3	2 (4.2)	0	0	2 (13.3)	0
Swelling/ Induration	Any	11 (22.9)	12 (26.7)	0	3 (20)	1 (4.3)
	Grade 3	0	0	0	1 (6.7)	0
Warmth	Any	14 (29.2)	10 (22.2)	1 (9.1)	4 (26.7)	1 (4.3)
	Grade 3	0	0	0	1 (6.7)	0
Systemic AEs
Any event, n (%)	Any	43 (89.6)	28 (62.2)	4 (36.4)	12 (80)	13 (56.5)
	Grade 3	11 (22.9)	0	1 (9.1)	3 (20)	1 (4.3)
Arthralgia	Any	22 (45.8)	2 (4.4)	1 (9.1)	4 (26.7)	1 (4.3)
	Grade 3	2 (4.2)	0	0	1 (6.7)	0
Chills	Any	31 (64.6)	4 (8.9)	0	7 (46.7)	0
	Grade 3	6 (12.5)	0	0	2 (13.3)	0
Fatigue	Any	36 (75)	20 (44.4)	3 (27.3)	9 (60)	6 (26.1)
	Grade 3	3 (6.3)	0	1 (9.1)	2 (13.3)	0
General itching	Any	5 (10.4)	3 (6.7)	1 (9.1)	1 (6.7)	1 (4.3)
	Grade 3	0	0	0	0	0
Headache	Any	38 (79.2)	14 (31.1)	1 (9.1)	9 (60)	7 (30.4)
	Grade 3	6 (12.5)	0	0	3 (20)	0
Myalgia	Any	28 (58.3)	6 (13.3)	2 (18.2)	6 (40)	1 (4.3)
	Grade 3	5 (10.4)	0	0	2 (13.3)	0
Nausea	Any	20 (41.7)	4 (8.9)	0	1 (6.7)	4 (17.4)
	Grade 3	1 (2.1)	0	0	1 (6.7)	1 (4.3)
Pyrexia	Any	10 (20.8)	1 (2.2)	0	2 (13.3)	0
	Grade 3	1 (2.1)	0	0	0	0
Rash	Any	0	1 (2.2)	1 (9.1)	0	0
	Grade 3	0	0	0	0	0
Vomiting	Any	5 (10.4)	1 (2.2)	0	0	2 (8.7)
	Grade 3	1 (2.1)	0	0	0	0

Ad26.F = Ad26.Filo; Ad26.Z = Ad26.ZEBOV; AEs = adverse events; Inf U = infectious units; MVA = MVA-BN-Filo; n (%) = number (percentage) of doses with one or more events.

^a MVA-BN-Filo at a dose of 1x10⁸ Inf U.