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. 2022 Oct 5;8(40):eabo0522. doi: 10.1126/sciadv.abo0522

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Fig. 4. — (A) BAL cell counts following either blank NP (dark gray circles) or γPNA/DNA NP (multicolored circles) treatment with CF (black circles) and wild-type (light gray circles) controls. Color coding of γPNA/DNA NP–treated animals is consistent throughout this figure, and each color represents a different mouse. γPNA/DNA NPs contain ~2 μg/0.2 nmol of PNA and ~2 μg/0.1 nmol of DNA per milligram; each animal received ~0.2 mg/kg of PNA and donor DNA per dose. (B) Schematic of ex vivo tissue isolation and Ussing chamber assay. Phenotypic ΔI_sc measurements in (C) nasal epithelium, (D) rectum, (E) distal colon, (F) ileum, (G) duodenum, and (H) jejunum following either 4 × 2 mg of blank NP (dark gray circles) or 4 × 2 mg of γPNA/DNA NP (multicolored circles) treatment with CF (black circles) and wild-type (light gray circles) controls.