Appendix 1—figure 5. Risk of death in the first 28 days after hospital admission or disease onset, whichever occurred latest, during pre-Omicron and Omicron periods.

In each panel, the x-axis shows countries, with different periods represented by circles with different colours (blue circles for the pre-Omicron period; red circles, for period after Omicron variant frequency reaches 90%). 95% confidence intervals are presented. The top panel shows data for individuals of all ages; the bottom panels, data for patients aged less than 18 years, between 18 and 60 years, and older than 60 years. Only countries with at least 50 observations in both study periods are included in the figure; for panels presenting age-specific estimates (bottom row), a further requirement for inclusion was outcome data for at least 10 patients in the corresponding age range in both periods.