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. 2022 Apr 30;4(2):42–47. doi: 10.1176/appi.prcp.20210042

FIGURE 3.

FIGURE 3

Reward‐related striatum activation pre‐ and post‐treatment. (A) Prior to treatment (left panel) we found no evidence of reward‐related activity, but rather indication of deactivation in several striatal regions, including the left posterior putamen (xyz = −30; −10; 8; T = 4.33; p = 0.002; 488 mm3), right dorsal putamen (xyz =  36; −14; −6; T = 4.00; p = 0.003; 1288 mm3), left dorsal caudate (xyz = −14; 20; 10; T = 3.25; p = 0.007; 592 mm3) and right nucleus accumbens (xyz =  8; 8; −12; T = 3.25; p = 0.007; 208 mm3). After treatment (right panel) we found evidence of substantial reward‐related activation encompassing the right nucleus accumbens (xyz =  6; 6; −6; T = 5.06; p = 0.001; 88 mm3), lateral putamen (left: xyz = −18; 10; −2; T = 4.37; p = 0.002; 2912 mm3: right: xyz = 24; 4; −2; T = 5.00; p = 0.001; 3936 mm3), and right dorsal caudate (xyz =  12; 8;−20; T = 3.72; p = 0.004; 1552 mm3). In addition, one small region in the medial left caudate showed deactivation (xyz = −6; 18; 4; T = 3.62; p = 0.004; 112 mm3). Red clusters indicate regions with significant reward‐related activity and blue clusters indicate deactivation, with no color‐coding for strength of activation. (B) When comparing the pre‐treatment to the post‐treatment contrast we found significant increases in reward‐related activity in several regions including right lateral putamen (xyz; 32; −4; 12; T = 4.15; p = 0.002; 3848 mm3), anterior left caudate (xyz = −14; 22; 10; T = 4.07; p = 0.002; 416 mm3), left posterior putamen (xyz = −28; −14; 10; T = 3.99; p = 0.003; 392 mm3), right dorsal caudate (xyz = 20; −2; 24; T = 3.30; p = 0.007; 104 mm3), left anterior putamen (xyz = −20; 10; 8; T = 2.95; p = 0.011; 512 mm3), right nucleus accumbens (8; 8; −10; T = 2.74; p = 0.014; 224 mm3), and no significant decreases. Clusters are color‐coded for strength of activation increases. Only voxels passing an uncorrected threshold of p<0.05 with at minimum cluster extent of 80 mm3 are shown. Numbers adjacent to brain images indicate MNI‐coordinates of the slice. Results are displayed on an MNI‐template.