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. Author manuscript; available in PMC: 2022 Oct 5.
Published in final edited form as: J Theor Biol. 2019 May 9;474:88–102. doi: 10.1016/j.jtbi.2019.05.005

Fig 6: Optimal treatment intensity is determined by the current level of resistance and the total time span of treatment.

Fig 6:

The temporal axis marks the direction from the start of a treatment (a positive number) to the terminal point of treatment. The threshold value 𝑇0 separates the trajectories with and without a dose-sparing regimen whose trajectory is marked by the dashed line. Trajectories of three regimens are illustrated (see description in the text). Trajectory colours indicate the applied treatment intensity (legend).