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. 2022 Sep 14;610(7930):135–142. doi: 10.1038/s41586-022-05196-w

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, Left, schematic of dLGN recording during saccades in TTX-blinded animals. Right, example neuron preferring temporal saccades. Raster plots (top) and PETH (bottom). b, Left, scatter plot of the response to nasal and temporal saccades (average spike count in a 100 ms window from saccade onset) for all responsive dLGN neurons (n = 108, 4 mice). Blue, prefer nasal saccades; red, prefer temporal saccades; gray, no statistical difference; green, example neuron in (a). Right, average PETH for preferred and non-preferred saccade directions (n = 77 neurons, 4 mice). Baseline normalized. Shaded area, average ± s.e.m. Vertical orange bar, 0–90% rise time of saccades (26 ms). c, Left, schematic of V1 recording during saccades under dLGN silencing. Right, example neuron preferring temporal saccades. Raster plots (top) and PETH (bottom). d, Left, scatter plot of the response to nasal and temporal saccades (average spike count in a 100 ms window from saccade onset) for all responsive V1 neurons (n = 125, 4 mice). Blue, prefer nasal saccades; red, prefer temporal saccades; gray, no statistical difference; green, example neuron in (c). Right, average PETH for preferred and non-preferred saccade directions (n = 64 neurons, 4 mice). Shaded area, average ± s.e.m. Vertical orange bar, 0–90% rise time of saccades (26 ms). P-values, comparison of activity for preferred and non-preferred saccade directions in 20-ms bins (see Methods). Note the persistence of directionally selective saccade responses in V1 despite dLGN silencing. e, Left, schematic of V1 recording during a brief (32 ms) presentation of a full-field grating (see Methods). Center, multi-unit response from an example recording. Raster plot (top) and PETH (bottom). Right, average PETH of 3 mice. Baseline normalized. Shaded area, average ± s.e.m. 173.5 ± 29% average increase in evoked FR ± s.e.m. f, Left and center, same as in (a), but for mice injected with muscimol-BODIPY in the dLGN. Right, average PETH of 4 mice. Recording started after muscimol injection. Response was measured both at the start of the recording session and at the end. Note the lack of visual response in both cases. Baseline normalized. Shaded area, average ± s.e.m. Average increase in evoked FR ± s.e.m. was −16.7 ± 7.5% (start) and 14.1 ± 8.8% (end). g, Section images of the four mice injected with muscimol-BODIPY in the dLGN in (b). Red, BODIPY. Scale bar, 1 mm.