Skip to main content
. 2022 Sep 28;25(10):1273–1278. doi: 10.1038/s41593-022-01170-x

Extended Data Fig. 9. Distribution of engulfment loci across OPCs is altered in response to sensory experience.

Extended Data Fig. 9

(a) Reconstructions of OPCs (NG2, green) and engulfment loci (VGluT2, magenta) illustrating experience-dependent changes in the distribution of points of engulfment across the OPC arbor. Scale bar, 3 μm. (b) Quantification of the distance between the center of the OPC soma and loci at which engulfed inputs reside. Two-tailed one-way ANOVA (P = 0.0131) with Tukey’s post-hoc test; n (OPC; P27/LDR/LDR + 10): 19/31/46, from 3 mice per group. (c) Estimated range of synaptic surveillance by a given OPC based upon the bounding box volume calculated from the distribution of engulfment loci as quantified in (b). Two-tailed, one-way ANOVA (P = 0.0003) with Tukey’s post-hoc test; (OPC; P27/LDR/LDR + 10): 22/30/42, from 3 mice per group. *P < 0.05. ***P < 0.001.