Table 1.

Liver biopsy findings among three patients.

Data are presented according to Ishak grading and staging.

	Case I (11 portal spaces)		Case II (12 portal spaces)		Case III (12 portal spaces)
Periportal or periseptal interface hepatitis	Severe (continuous around > 50% of portal areas). Moderate plasma cells infiltrate	4	Mild/moderate (focal, most portal areas). Scattered plasma cells and eosinophils	2	Moderate (continuous around <50% of tracts). Moderate plasma cells infiltrate	3
Confluent necrosis	Zone 3 necrosis in some areas	2	Absent	0	Absent	0
Focal (spotty) lytic necrosis, apoptosis and focal inflammation	Five to ten foci per 10X objective, perivenular necroinflammatory infiltrate	3	Two to four foci per 10X objective, perivenular necroinflammatory infiltrate	2	One focus per 10X objective	1
Portal inflammation	Marked, all portal areas	4	Mild, focal inflammation	1	Moderate, all portal areas	3
Fibrosis	No fibrosis	0	Fibrous expansion of some portal areas, without septa	1	Fibrous expansion of most portal areas, with short fibrous septa	2
Other features	Mild bile duct injury		Focal ductular hyperplasia, no rosettes		Mild biliary regression, focal rosettes