Table 1.
Comparison of histopathologic findings between IgAN patients with and without Crohn’s disease
| Characteristics | CD-IgAN (n = 18) |
NOS-IgAN (n = 11) |
p-value |
|---|---|---|---|
| Mean ± SD | Mean ± SD | ||
| Glomerular lesions | |||
| Global glomerular sclerosis (%) | 29.6 ± 31.3 | 5.1 ± 6.0 | 0.023* |
| Crescent in active (%) | 7.5 ± 10.7 | 1.9 ± 3.4 | NS (0.22) |
| Crescent in active (%) in patients treated with steroids | 12.3 ± 11.1a | 2.3 ± 3.7b | 0.020* |
| Oxford classification score (MEST-C) | |||
| M | 0.44 ± 0.51 | 0.18 ± 0.40 | NS (0.234) |
| E | 0.06 ± 0.24 | 0.00 ± 0.00 | NS (1.00) |
| S | 0.22 ± 0.43 | 0.00 ± 0.00 | NS (0.268) |
| T | 0.56 ± 0.71 | 0.00 ± 0.00 | 0.046* |
| C | 0.33 ± 0.49 | 0.18 ± 0.40 | NS (0.671) |
| Tubulo-interstitial lesions | |||
| IF/TA grade (grade)c | 1.50 ± 0.99 | 0.36 ± 0.50 | 0.017* |
| Inflammatory cell infiltration (grade)d | 1.17 ± 0.62 | 0.64 ± 0.50 | NS (0.092) |
| Vascular sclerotic lesions | |||
| Arteriolar hyalinosis (grade)d | 0.61 ± 0.61 | 0.0 ± 0.0 | 0.003** |
| Interlobular arteriosclerosis (grade)d,e |
0.21 ± 0.43 (n = 14) |
0.25 ± 0.46 (n = 8) |
NS (1.00) |
| Macrophage infiltration (by CD68 staining) | |||
| Glomerular CD68( +) cell infiltration (grade)f | 1.45 ± 0.51 | 1.13 ± 0.83 | 0.02* |
| Interstitial CD68( +) cell infiltration (grade)g | 2.06 ± 0.68 | 1.13 ± 0.35 | 0.011* |
Mann–Whitney U test or Fisher’s test were used for statistical analysis
Abbreviations: IF/TA interstitial fibrosis/tubular atrophy, CD-IgAN immunoglobulin A nephropathy patients with Crohn’s disease, NOS-IgAN immunoglobulin A nephropathy patients without Crohn’s disease, NS not significant
*p < 0.05; **p < 0.01
aNine patients in the CD-IgAN group were treated with steroids
bNine patients in the NOS-IgAN group were treated with steroid
CThe grade of interstitial fibrosis and tubular atrophy (IF/TA) was classified into five based on the percentage of the total cortical area affected: 0 (0–5%), 1 (6–25%), 2 (26–50%), 3 (51–75%), and 4 (76–100%)
dThe grade was classified into four grades: 0 (absent), 1 (mild), 2 (moderate), and 3 (severe)
eThe interlobular artery was not detected in 4 and 3 patients in the CD-IgAN and NOS-IgAN groups, respectively
fThe grade of glomerular CD68 ( +) cell infiltration was classified into four: 0 (none), 1 (mild, < 5 cells/glomerulus), 2 (moderate, 5–9 cells/glomerulus), and 3 (severe, ≥ 10 cells/glomerulus). CD68 immunohistochemical staining was performed in 16 and 8 patients in the CD-IgAN and NOS-IgAN groups, respectively
gThe grade of interstitial CD68 ( +) cell infiltration was classified into four: 0 (none), 1 (mild), 2 (moderate), and 3 (severe)