Table 2.
Comparison of immunohistochemical intensity of glomerular IgA, IgA subclass, Gd-IgA1, and C3 deposition between IgAN patients with and without Crohn’s disease
| Glomerular deposition by immunohistochemistry | CD-IgAN (n = 18) |
NOS-IgAN (n = 11) |
p-value |
|---|---|---|---|
| Mean ± SD | Mean ± SD | ||
| IgA | 2.26 ± 0.67 | 2.49 ± 0.42 | NS (0.520) |
| IgA1 | 1.83 ± 0.86 | 2.66 ± 0.80 | 0.029* |
| IgA2 | 1.39 ± 0.86 | 1.77 ± 0.64 | NS (0.155) |
| IgA2/IgA1 | 0.78 ± 0.27 | 0.70 ± 0.26 | NS (0.469) |
| Galactose-deficient IgA1 | 1.17 ± 0.79 | 1.52 ± 0.65 | NS (0.240) |
| C3a | 1.57 ± 1.02 | 2.22 ± 0.67 | NS (0.543) |
Mann–Whitney U test or Fisher’s test was used for statistical analysis. Values were expressed as mean ± SD. The grade of each patient was obtained by dividing the total of the deposition grade of IgA, IgA1, IgA2, and Gd-IgA1 in each glomerulus by the total number of glomeruli
Abbreviations: CD-IgAN immunoglobulin A nephropathy patients with Crohn’s disease, NOS-IgAN immunoglobulin A nephropathy patients without Crohn’s disease, NS not significant
*p < 0.05
aThe grade of C3 deposition was determined by performing routine immunofluorescent examination using frozen section and classified into 4 grades: 0 (non), 1 (mild), 2 (moderate), and 3 (severe). C3 deposition could not be evaluated in 4 and 2 patients in the CD-IgAN and NOS-IgAN groups, respectively