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. 2022 Oct 5;8:101. doi: 10.1038/s41421-022-00445-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a t-SNE plot showing eight color-coded myeloid cell clusters, including six macrophage clusters and two dendritic cell clusters. b Bubble heatmap showing expression levels of marker genes across macrophage and dendritic cell subsets. c Heatmap showing preferential enrichment of eight myeloid cell clusters across CCs, PTs, and MTs. Ro/e > 1 indicates significant enrichment. d Violin plot showing expression of representative gene signatures among dendritic cell subsets. e Violin plots showing expression of functional gene sets across macrophage clusters (from right top to bottom: innate host defenders against microbes; HLA molecules; markers for angiogenesis and hypoxia; complement components; inflammatory chemokines). f Heatmap showing top-ranking DEGs for each macrophage subset. g Heatmap displaying functional assignment of each macrophage cluster. TAM, tumor-associated macrophage; MDSC, myeloid-derived suppressor cells. h Heatmap showing the relative abundance of functional macrophage subsets across CCs, PTs, and MTs. i, j Dot plots showing typically significantly enriched GO terms across macrophage clusters.