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. 2022 Oct 5;12:16625. doi: 10.1038/s41598-022-20572-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of Ahr has a major impact on the serum metabolome of mice. (A) Principal component analysis reveals separation between the Ahr^−/− and Ahr^+/+ mice. (B) Of the 965 surveyed metabolites, 290 were significantly altered (p < 0.05), with 138 elevated and 152 decreased. (C) Heatmap of the most significantly altered non-lipids (Partially Characterized Molecules, Peptides, Xenobiotics, Amino Acids, Nucleotides, Cofactors and Vitamins, Energy, and Carbohydrate superpathways) show the differences between Ahr^−/− (n = 7) and Ahr^+/+ (n = 5). (D) The Lipid superpathway, the largest measured superpathway, also has several altered metabolites. Heatmaps were generated using the ComplexHeatmap in R software environment.