Figure 1.
Loss of Ahr has a major impact on the serum metabolome of mice. (A) Principal component analysis reveals separation between the Ahr−/− and Ahr+/+ mice. (B) Of the 965 surveyed metabolites, 290 were significantly altered (p < 0.05), with 138 elevated and 152 decreased. (C) Heatmap of the most significantly altered non-lipids (Partially Characterized Molecules, Peptides, Xenobiotics, Amino Acids, Nucleotides, Cofactors and Vitamins, Energy, and Carbohydrate superpathways) show the differences between Ahr−/− (n = 7) and Ahr+/+ (n = 5). (D) The Lipid superpathway, the largest measured superpathway, also has several altered metabolites. Heatmaps were generated using the ComplexHeatmap in R software environment.