Table 1.
Elevated metabolites in the Ahr knockout cover a wide range of biochemical pathways, with many showing fold changes greater than 2.
| Metabolite | Pubchem ID | Superpathway | Subpathway | Fold change | p-value | q-value |
|---|---|---|---|---|---|---|
| Cholate | 221493 | Lipid | Primary bile acid metabolism | 14.60 | 0.0137 | 0.0310 |
| Hydroxymethylpyrimidine | 777 | Cofactors and vitamins | Thiamine metabolism | 13.09 | 0.0000 | 0.0000 |
| Beta-muricholate | 5283853 | Lipid | Primary bile acid metabolism | 12.85 | 0.0186 | 0.0350 |
| chenodeoxycholate | 10133 | Lipid | Primary bile acid metabolism | 11.85 | 0.0036 | 0.0217 |
| 3-dehydrocholate | 159655 | Lipid | Secondary bile acid metabolism | 11.15 | 0.0051 | 0.0244 |
| p-cresol glucuronide* | 154035 | Amino acid | Tyrosine metabolism | 10.94 | 0.0032 | 0.0204 |
| 4-vinylphenol sulfate | 6426766 | Xenobiotics | Benzoate metabolism | 10.47 | 0.0000 | 0.0042 |
| phenylacetylcarnitine | 101724840 | Peptide | Acetylated peptides | 7.66 | 0.0003 | 0.0071 |
| Ophthalmate | 7018721 | Amino acid | Glutathione metabolism | 6.86 | 0.0189 | 0.0351 |
| Azelate (C9-DC) | 2266 | Lipid | Fatty acid, dicarboxylate | 6.84 | 0.0077 | 0.0262 |
| Spermidine | 1102 | Amino acid | Polyamine metabolism | 3.51 | 0.0158 | 0.0332 |