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. 2022 Oct 5;13:5871. doi: 10.1038/s41467-022-33323-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic representation of the deletion of Bnc1 exon 4 in oocytes of pre-follicles, PrFs by using Ddx4 and Gdf9-Cre transgenic. b Ovary weight, body weight and ovary weight/body weight ratios of Bnc1^loxP/loxP, Cre (−) (n = 9), Bnc1^loxP/loxP, Ddx4-Cre (+) (n = 7, p value = 0.0069 for ovary weight, p value = 0.2647 for body weight, p value = 0.0003 for ovary weight/body weight) and Bnc1^loxP/loxP, Gdf9-Cre (+) (≥3, p value = 0.0179 for ovary weight, p value = 0.2835 for body weight, p value = 0.0029 for ovary weight/body weight) mice at 36 weeks. c Average litter sizes of Bnc1^loxP/loxP, Cre (−) (n = 4), Bnc1^loxP/loxP, Ddx4-Cre (+) (n = 5, p value < 0.0001) and Bnc1^loxP/loxP, Gdf9-Cre (+) (n = 4, p value < 0.0001) female mice. d Comparison of follicle numbers of Bnc1^loxP/loxP, Cre (−) (n = 3), Bnc1^loxP/loxP, Ddx4-Cre (+) (n = 3, p value < 0.0001 for PrFs, p value = 0.0060 for PFs, p value = 0.2081 for SFs and p value = 0.0667 for AFs) and Bnc1^loxP/loxP, Gdf9-Cre (+) (n = 3, p value = 0.0002 for PrFs, p value = 0.0620 for PFs, p value = 0.7357 for SFs and p value = 0.1135 for AFs) mice at 36 weeks. Scale bar = 500 μm. e GV oocytes obtained from Bnc1^loxP/loxP, Cre (−) and Bnc1^loxP/loxP, Gdf9-Cre (+) mice at 4 (n = 4) and 12 (n = 4) weeks old (p value = 0.0022 for 4 weeks old, p value = 0.0398 for 12 weeks old). f Comparison of follicle numbers of Bnc1^loxP/loxP, Cre (−) and Bnc1^loxP/loxP, Gdf9-Cre (+) mice at 4 weeks (n = 3, p value = 0.7145 for growing follicles, p value = 0.0091 for growing follicles/PrFs, p value = 0.0206 for PrFs, p value = 0.6640 for PFs, p value = 0.1959 for SFs, p value = 0.03219 for AFs and p value = 0.0065 for AtFs). g Comparison of follicle numbers of Bnc1^loxP/loxP, Cre (−) and Bnc1^loxP/loxP, Gdf9-Cre (+) mice at 16 weeks (n = 3, p value = 0.2046 for growing follicles, p value = 0.0287 for growing follicles/PrFs, p value = 0.0074 for PrFs, p value = 0.1718 for PFs, p value = 0.3858 for SFs, p value = 0.0219 for AFs and p value = 0.0011 for AtFs). Scale bar = 500 μm. The error bars indicate the mean values ± SDs, unpaired t test, two-tailed, *p value < 0.05, **p value < 0.01 and ***p value < 0.001. Source data are provided as a Source Data file.