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. 2022 Oct 5;13:5871. doi: 10.1038/s41467-022-33323-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Immunofluorescence of NF2 and active YAP in GV oocytes (p value < 0.0001 for NF2 of Bnc1^tr/tr Con, p value = 0.0120 for NF2 of Bnc1^tr/tr Nf2 mRNA, p value < 0.0001 for nuclear/cytoplasmic YAP of Bnc1^tr/tr Con, p value = 0.0023 for nuclear/cytoplasmic YAP of Bnc1^tr/tr Nf2 mRNA, 3 independent experiments with total oocyte numbers >30 oocytes). b HE staining and PrFs, PFs, SFs and AFs of Bnc1^+/+ Con (n = 3), Bnc1^tr/tr Con (n = 3, p value = 0.0008 for PrFs, p value = 0.4975 for PFs, p value = 0.1942 for SFs, p value = 0.0019 for AFs, p value = 0.3379 for growing follicles and p value = 0.0007 for growing follicles/PrFs) and Bnc1^tr/tr VP (n = 3, p value = 0.0013 for PrFs, p value = 0.7104 for PFs, p value = 0.3955 for SFs, p value = 0.3796 for AFs, p value = 0.2134 for growing follicles and p value = 0.0012 for growing follicles/PrFs) mice at 3 weeks old. Scale bar = 600 μm. c IHC of COX2 and TFRC in Bnc1^+/+ Con (n = 3), Bnc1^tr/tr Con (n = 3) and Bnc1^tr/tr VP (n = 3) mouse ovaries. d TFRC in mouse GV oocytes of Bnc1^+/+ Con, Bnc1^tr/tr Con (p value = 0.0005) and Bnc1^tr/tr VP (p value = 0.0315) group at 3 weeks old. e Fe²⁺ concentration in Bnc1^+/+ Con, Bnc1^tr/tr Con (p value=0.0115) and Bnc1^tr/tr VP (p value < 0.0001) mouse GV oocytes at 3 weeks old. f Lipid ROS in Bnc1^+/+ Con, Bnc1^tr/tr Con (p value < 0.0001 for oxidized lipids, p value < 0.0001 for reduced lipids and p value < 0.0001 for oxidized/reduced lipids) and Bnc1^tr/tr VP (p value < 0.0001 for oxidized lipids, p value < 0.0001 for reduced lipids and p value < 0.0001 for oxidized/reduced lipids) mouse GV oocytes at 3 weeks old. The error bars indicate the mean values ± SDs, unpaired t test, two-tailed, 3 independent experiments with total oocyte numbers >30 oocytes. Source data are provided as a Source Data file.