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. 2022 Oct 5;13:5871. doi: 10.1038/s41467-022-33323-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Gross of Bnc1^+/+ Con (n = 3), Bnc1^tr/tr Con (n = 3) and Bnc1^tr/tr Fer-1 (n = 3) mice at 16 weeks old. b The ovary weights, body weights and ovarian weight coefficients of Bnc1^+/+ Con (n = 4), Bnc1^tr/tr Con (n = 6, p value = 0.0003 for ovary weight, p value = 0.4137 for body weight and p value = 0.0009 for ovary weight/body weight) and Bnc1^tr/tr Fer-1 (n = 4, p value = 0.0077 for ovary weight, p value = 0.4395 for body weight and p value = 0.0068 for ovary weight/body weight) mice at 16 weeks old. c HE staining of PrFs, PFs, SFs, AFs and AtFs of Bnc1^+/+ Con (n = 3), Bnc1^tr/tr Con (n = 3, p value = 0.0073 for PrFs, p value = 0.3055 for PFs, p value = 0.3015 for SFs, p value = 0.3501 for AFs, p value = 0.0382 for AtFs, p value = 0.3957 for growing follicles and p value = 0.0002 for growing follicles/PrFs) and Bnc1^tr/tr Fer-1 (n = 3, p value = 0.4860 for PrFs, p value = 0.8158 for PFs, p value = 0.2028 for SFs, p value = 0.4977 for AFs, p value = 0.0471 for AtFs, p value = 0.6138 for growing follicles and p value = 0.4052 for growing follicles/PrFs) mice at 16 weeks old. Scale bar = 200 μm. d Estrous cycles of Bnc1^+/+ Con (n = 8), Bnc1^tr/tr Con (n = 8, p value = 0.2186 for proestrus, p value = 0.1167 for estrus, p value = 0.2377 for metestrus and p value = 0.0073 for diestrus) and Bnc1^tr/tr Fer-1 (n = 5, p value = 0.1956 for proestrus, p value = 0.5312 for estrus, p value = 0.0536 for metestrus and p value = 0.0108 for diestrus) mice. e Lipid ROS in Bnc1^+/+ Con, Bnc1^tr/tr Con (p value < 0.0001 for oxidized lipids, p value < 0.0001 for reduced lipids and p value = 0.0052 for oxidized/reduced lipids) and Bnc1^tr/tr Fer-1 (p value = 0.0083 for oxidized lipids, p value < 0.0001 for reduced lipids and p value = 0.0006 for oxidized/reduced lipids) mouse GV oocytes at 16 weeks old. 3 independent experiments with total oocyte numbers >30 oocytes). f IHC of GPX4 and COX2 in Bnc1^+/+ Con (n = 3), Bnc1^tr/tr Con (n = 3) and Bnc1^tr/tr Fer-1 (n = 3) mouse ovaries. The error bars indicate the mean values ± SDs, unpaired t test, two-tailed, *p value < 0.05, **p value < 0.01 and ***p value < 0.001. Source data are provided as a Source Data file.