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. 2022 Sep 21;54(9):1549–1562. doi: 10.1038/s12276-022-00849-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a A cluster heatmap showing differentially expressed proteins with over 2-fold changes between LFH and non-LFH samples. Red denotes elevated levels, while green denotes decreased levels. Red arrow denotes CLU. b Top 10 up- and top 10 downregulated proteins. Levels of CLU protein in LFH were elevated by >30-fold compared with the control. GO and KEGG pathway analysis. c–e GO terms for differentially expressed proteins (p < 0.05). The color shows the enrichment scores (−lg(p-value)), and the number of proteins tested is proportional to the marker area of the bubble of the significantly enriched GO terms. c Biological process (BP) GO terms. d Cellular component (CC) GO terms. e Molecular function (MF) GO terms. f Pathways associated with differentially expressed proteins in LFH (p < 0.05). g Protein‒protein interaction (PPI) analysis using the STRING tool showing functional association networks of differentially expressed proteins. The associations between nodes are connected with solid lines. Red marked rectangle shows CLU-TGF-β1 interactions.