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. 2022 Sep 21;54(9):1549–1562. doi: 10.1038/s12276-022-00849-2

Fig. 7. CLU ameliorates mechanical stress-induced LFH in vivo.

Fig. 7

a Representative images of H&E, EVG, and Masson staining of tissues from mice under different treatments for 8 weeks. The scale bar indicates 50 μm. b–d Quantitative analysis of the LF area and the ratio of collagen fibers to elastic fibers in EVG and Masson-stained sections (n = 6 mice in each group). Data are expressed as the mean ± S.D. **P < 0.01. ns, not significant. e, g Representative images of immunohistochemical staining for p-SMAD3 and α-SMA in mouse tissues under different treatments after 8 weeks. The scale bar indicates 50 μm. f, h Quantitative analysis of the ratio of p-SMAD3-positive cells and α-SMA-positive cells (n = 6 mice in each group). Data are expressed as the mean ± S.D. **P < 0.01. ns, not significant.