Table 2.

Hazard ratios by outcome and antidepressant class at 5-year follow-up

					Age and gender adjusted		Fully adjusted
Antidepressant class	Participants	Observations	Events	Person-years	Hazard ratio	95% CI	Hazard ratio	95% CI
Diabetes	114 076	124 239	961	545 735
No antidepressant			872	495 551	1.00
Any antidepressant			89	50 185	1.28	(1.03–1.59)	0.83	(0.66–1.04)
SSRIs			62	46 557	0.91	(0.72–1.14)	0.64	(0.49–0.83)
Other antidepressant			38	11 503	2.03	(1.47–2.81)	1.13	(0.81–1.57)
Hypertension	107 316	117 025	2621	508 852
No antidepressant			2411	460 887	1.00		1.00
Any antidepressant			210	47 965	1.02	(0.89–1.18)	0.93	(0.81–1.08)
SSRIs			161	38 986	1.02	(0.89–1.18)	0.91	(0.77–1.07)
Other antidepressant			49	8991	1.15	(0.87–1.53)	1.02	(0.77–1.36)
CV	121 190	132 313	337	581 598
No antidepressant			306	526 413	1.00		1.00
Any antidepressant			31	55 186	1.17	(0.81–1.70)	1.04	(0.72–1.52)
SSRIs			25	43 784	1.24	(0.86–1.79)	1.12	(0.74–1.69)
Other antidepressant			7	10 619	1.18	(0.56–2.49)	1.15	(0.54–2.43)
CHD	80 964	87 972	545	388 540
No antidepressant			492	353 972	1.00		1.00
Any antidepressant			53	34 568	1.63	(1.22–2.17)	1.47	(1.10–1.95)
SSRIs			41	28 448	1.55	(1.15–2.08)	1.44	(1.04–1.99)
Other antidepressant			13	6177	1.78	(1.03–3.09)	1.59	(0.91–2.77)
CVD mortality	113 800	124 084	150	546 926
No antidepressant			135	495 849	1.00		1.00
Any antidepressant			15	51 077	1.53	(0.89–2.61)	1.21	(0.70–2.10)
SSRIs			11	41 490	1.24	(0.68–2.25)	1.16	(0.62–2.18)
Other antidepressant			4	10 220	1.50	(0.56–4.05)	1.14	(0.42–3.11)
All-cause mortality	101 609	110 788	746	488 286
No antidepressant			649	442 834	1.00		1.00
Any antidepressant			97	45 452	1.79	(1.45–2.23)	1.37	(1.10–1.70)
SSRIs			76	36 649	1.44	(1.14–1.83)	1.41	(1.11–1.80)
Other antidepressant			27	9686	1.89	(1.29–2.78)	1.30	(0.88–1.92)

SSRI, selective serotonin reuptake inhibitor; CV, cerebrovascular disease; CHD, coronary heart disease; CVD, cardiovascular disease.