Table 3.

Hazard ratios by outcome and antidepressant class at 10-year follow-up

					Age and gender adjusted		Fully adjusted
Antidepressant class	Participants	Observations	Events	Person-years	Hazard ratio	95% CI	Hazard ratio	95% CI
Diabetes	98 338	109 681	1456	890 085
No antidepressant			1352	817 492	1.00
Any antidepressant			104	72 592	1.12	(0.92–1.37)	0.77	(0.63–0.94)
SSRIs			72	59 606	1.13	(0.94–1.36)	0.68	(0.53–0.87)
Other antidepressant			47	15 814	2.01	(1.50–2.68)	1.17	(0.87–1.57)
Hypertension	92 524	103 416	3777	825 174
No antidepressant			3545	755 910	1.00		1.00
Any antidepressant			232	69 263	0.86	(0.75–0.98)	0.80	(0.70–0.91)
SSRIs			182	57 514	0.83	(0.73–0.94)	0.77	(0.66–0.89)
Other antidepressant			51	11 835	1.19	(0.97–1.46)	0.96	(0.73–1.26)
CV	105 536	118 030	693	962 201
No antidepressant			625	882 022	1.00		1.00
Any antidepressant			68	80 179	1.42	(1.10–1.83)	1.26	(0.97–1.62)
SSRIs			57	66 283	1.44	(1.13–1.84)	1.34	(1.02–1.77)
Other antidepressant			11	14 035	1.12	(0.62–2.04)	0.97	(0.54–1.77)
CHD	79 938	89 029	1015	728 001
No antidepressant			934	669 588	1.00		1.00
Any antidepressant			81	58 413	1.49	(1.18–1.87)	1.32	(1.04–1.66)
SSRIs			56	76 620	1.38	(1.10–1.73)	1.15	(0.87–1.51)
Other antidepressant			23	9320	2.25	(1.48–3.40)	1.99	(1.31–3.01)
CVD mortality	103 567	115 732	454	947 147
No antidepressant			389	868 874	1.00		1.00
Any antidepressant			65	78 273	2.54	(1.94–3.32)	1.89	(1.44–2.49)
SSRIs			50	64 864	1.92	(1.43–2.57)	1.87	(1.38–2.53)
Other antidepressant			15	13 409	2.71	(1.62–4.55)	1.86	(1.10–3.15)
All-cause mortality	81 279	90 508	1752	745 059
No antidepressant			1511	685 708	1.00		1.00
Any antidepressant			241	59 352	2.23	(1.94–2.56)	1.86	(1.61–2.14)
SSRIs			181	49 651	1.68	(1.44–1.96)	1.73	(1.48–2.03)
Other antidepressant			63	10 127	2.82	(2.19–3.63)	2.20	(1.71–2.84)

SSRI, selective serotonin reuptake inhibitor; CV, cerebrovascular disease; CHD, coronary heart disease; CVD, cardiovascular disease.