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. 2022 Oct 5;5:1060. doi: 10.1038/s42003-022-04034-z

Fig. 4. ACOX2 is a peroxisomal marker for ISR.

Fig. 4

a Quantification of Acox2 mRNA expression in QF muscle of Grpel1skm −/− mice (n = 4 per genotype). b Timeline showing the induction of ACOX2, ATF4 and ATF5 mRNA expression in human fibroblasts (C1 and C2 are independent control fibroblast lines) after treatment with actinonin, compared with vehicle (ethanol). c Quantification of ATF4 and ACOX2 mRNA expression after siRNA-mediated knockdown of ATF4 followed by 24 h of actinonin treatment (n = 3 per treatment). d Quantification of ATF5 and ACOX2 mRNA expression after siRNA-mediated knockdown of ATF5 followed by 24 h of actinonin treatment (n = 3 per treatment).