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. 2022 Sep 21;54(9):1563–1576. doi: 10.1038/s12276-022-00853-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a HCT 116 cells were treated with A3373 in a time- (for 36 h) and dose-dependent (at 2 μM) manner in the presence of 1% serum. The lysates were analyzed by immunoblotting. b CRC cells were treated with A3373 (2 μM) for 12 h, and the lysates were immunoprecipitated and/or immunoblotted with the indicated antibodies. c Effect of A3373 on Wnt3a (150 ng/mL)-induced TCF transactivation in HEK293 cells. d Effect of A3373 on β-catenin-mediated TCF transactivation in HEK293 cells. e Effect of A3373 on the sphere-forming capacity of DLD1 cells. Limiting dilution assays were performed by diluting sphere-cultured cells. f Effect of A3373 on Wnt3a-induced migration and invasion. The results are representative of at least three independent experiments and presented as the mean ± SD. ***P < 0.001.