TABLE 1.
Characteristics of asthma and lung function in participating cohorts
| Cohort name (country) | Age at outcome, years | Participants, n | Asthma, % (n) | FEV1, z-score | FVC, z-score | FEV1/FVC, z-score | FEF75%, z-score |
| ABIS (Sweden) | 5 | 12 618 | 4.6 (578) | NA | NA | NA | NA |
| ALSPAC (UK) | 8 | 8376 | 21.7 (1605) | −0.34±1.01 | −0.50±1.02 | 0.42±1.07 | NA |
| BAMSE (Sweden) | 8 | 3402 | 12.4 (420) | 0.46±0.95 | 0.65±0.93 | −0.36±0.89 | NA |
| BiB (UK) | 5 | 2674 | 8.3 (223) | NA | NA | NA | NA |
| BILD (Switzerland) | 6 | 254 | 5.6 (14) | −0.00±0.95 | −0.19±0.97 | 0.41±0.97 | NA |
| CoNER (Italy) | 8 | 214 | 6.1 (13) | −1.02±0.87 | 1.73±0.80 | 1.80±0.50 | NA |
| COPSAC 2000 (Denmark) | 7 | 290 | 19.7 (57) | −0.26±1.09 | −0.58±1.06 | 0.78±1.17 | 2.01±1.14 |
| COPSAC 2010 (Denmark) | 5 | 550 | 22.4 (123) | −0.11±1.00 | −0.18±1.00 | 0.17±0.98 | 1.53±0.92 |
| DNBC (Denmark) | 7 | 34 437 | 15.2 (5250) | NA | NA | NA | NA |
| EDEN (France) | 6 | 900 | 18.6 (167) | −1.3±1.65 | −1.63±1.65 | 0.87±1.12 | 1.33±1.93 |
| FLEHS (Belgium) | 10 | 110 | 7.3 (8) | NA | NA | NA | NA |
| GASPII (Italy) | 9 | 464 | 13.1 (61) | −0.01±0.88 | 0.05±0.76 | −0.15±0.97 | NA |
| Generation R (Netherlands) | 10 | 5441 | 9.3 (436) | 0.15±0.98 | 0.19±0.93 | −0.11±0.96 | 0.02±0.92 |
| Generation XXI (Portugal) | 7 | 5485 | 6.1 (331) | 0.56±0.96 | 0.38±0.94 | 0.29±0.89 | 1.39±1.93 |
| GINI (Germany) | 15 | 1965 | 12.9 (217) | −0.58±0.92 | −0.53±0.90 | −0.11±1.00 | −0.13±0.95 |
| HUMIS (Norway) | 9 | 2384 | 5.3 (127) | NA | NA | NA | NA |
| INMA Gipuzkoa (Spain) | 4 | 277 | NA | −0.60±1.15 | −0.54±1.15 | −0.05±0.91 | −0.16±1.00 |
| INMA Menorca (Spain) | 12 | 422 | 6.4 (27) | −0.16±1.07 | 0.01±1.13 | −0.24±1.19 | −0.06±1.13 |
| INMA Sabadell (Spain) | 4 | 406 | NA | −0.57±1.30 | −0.48±1.37 | −0.08±1.03 | −0.25±1.13 |
| INMA Valencia (Spain) | 8 | 455 | NA | 0.30±1.08 | 0.30±1.10 | −0.04±0.95 | 0.04±0.90 |
| Isle of Wight (UK) | 10 | 1327 | 19.9 (264) | NA | NA | NA | NA |
| KOALA (Netherlands) | 7 | 1875 | 7.6 (141) | −0.13±0.95 | 0.16±0.94 | −0.55±0.84 | NA |
| LRC (UK) | 12 | 3978 | 20.3 (809) | −0.11±1.17 | −0.16±1.09 | 0.23±1.05 | 0.20±0.98 |
| Lifeways Cross-Generation Cohort Study (Ireland) | 9 | 138 | 6.5 (9) | NA | NA | NA | NA |
| LISA (Germany) | 15 | 941 | 9.7 (77) | −0.50±0.93 | −0.44±0.97 | −0.12±0.98 | −0.12±0.90 |
| LucKi (Netherlands) | 6 | 337 | 15.4 (52) | NA | NA | NA | NA |
| LUKAS (Finland) | 6 | 374 | 9.9 (37) | −0.08±1.09 | 0.30±1.00 | −0.73±0.84 | −0.48±1.01 |
| MAS-90 (Germany) | 7 | 826 | 6.6 (44) | 0.28±1.09 | 0.06±0.91 | 0.41±1.00 | NA |
| Millennium Cohort Study (UK) | 11 | 14 917 | 15.3 (2284) | NA | NA | NA | NA |
| MoBa (Norway) | 7 | 34 542 | 10.6 (3677) | NA | NA | NA | NA |
| NINFEA (Italy) | 7 | 1072 | 3.0 (32) | NA | NA | NA | NA |
| PELAGIE (France) | 6 | 941 | 11.3 (106) | NA | NA | NA | NA |
| PIAMA (Netherlands) | 11 | 2810 | 11.3 (299) | 0.52±0.92 | 0.37±0.87 | 0.21±1.01 | NA |
| REPRO_PL (Poland) | 7 | 106 | 2.1 (2) | 0.33±1.20 | 0.23±1.16 | 0.18±1.15 | 2.22±1.05 |
| Rhea (Greece) | 7 | 596 | 9.3 (55) | −0.01±1.16 | 0.18±1.18 | −0.33±1.03 | −0.22±1.06 |
| STEPS (Finland) | 5 | 713 | 8.3 (59) | NA | NA | NA | NA |
| SWS (UK) | 6 | 2033 | 14.1 (287) | 0.02±0.96 | −0.12±1.03 | −0.14±1.08 | NA |
| WHISTLER (Netherlands) | 5 | 1438 | 8.1 (116) | 0.43±1.06 | −0.38±1.00 | 1.71±0.87 | 1.99±0.79 |
| Total | Median 7 | 150 090 | 12.3 (18 007) | −0.02±1.10 | −0.03±1.11 | 0.03±1.07 | 0.35±1.37 |
z-scores for lung function measurements are presented as mean±sd. NA: not available.