TABLE 3.

Associations of any early-life upper and lower respiratory tract infections with school-age asthma, stratified for early-life wheezing

	Asthma, no early-life wheezing OR (95% CI)	Asthma, early-life wheezing OR (95% CI)
Upper respiratory tract infections
6 months	1.11 (1.03–1.21)**	1.03 (0.87–1.22)
1 year	1.19 (1.08–1.32)**	1.22 (1.06–1.41)**
2 years	1.20 (1.04–1.37)*	1.14 (0.95–1.37)
3 years	1.17 (1.06–1.30)**	1.00 (0.86–1.16)
4 years	1.19 (1.01–1.41)*	1.01 (0.86–1.19)
Lower respiratory tract infections
6 months	2.09 (1.45–3.01)**	1.40 (1.18–1.66)**
1 year	2.28 (1.97–2.66)**	1.87 (1.63–2.13)**
2 years	2.25 (1.89–2.68)**	1.87 (1.59–2.20)**
3 years	2.67 (2.12–3.35)**	1.43 (1.21–1.69)**
4 years	2.54 (1.98–3.28)**	1.45 (1.17–1.80)**

Data are presented as odds ratio with 95% confidence interval, derived from multilevel logistic regression models. Models are adjusted for maternal history of asthma and atopy, ethnicity, education level, smoking during pregnancy, parity and pet keeping, and child's sex, gestational age at birth, birthweight, season of birth, breastfeeding and daycare attendance. Early-life wheezing reflects wheezing at the same age as upper or lower respiratory tract infections. *: p<0.05; **: p<0.01.