Fig. 2.

Schematic representation and structure of PROTAC and Molecular Glue. A) Schematic representation of PROTAC. Bifunctional PROTAC contains a ligand targeting E3 ubiquitin ligase, a linker, and a warhead targeting POI. B) Modular design of PROTACs. C) Schematic representation of molecular glue. Molecular glue induces the protein–protein interaction between POI and E3 ubiquitin ligase by binding to E3 ubiquitin ligase or POI. D) Chemical structures of nature product-based glue. E) Chemical structures of synthetic glue.