Table 2.
Applications of Trim-Away Technology.
| Targets | Target Module | Projects | Ref. |
|---|---|---|---|
| RIF1 | Monoclonal, rabbit anti-RIF1 Antibody | Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice | [100] |
| TRF1 | Monoclonal, rat anti-TRF1 Antibody | TRF1 Depletion Reveals Mutual Regulation Between Telomeres, Kinetochores, and Inner Centromeres in Mouse Oocytes. | [101] |
| BCR/ABL | Monoclonal, rabbit anti-BCR/ABL antibody | Intracellular delivery of anti-BCR/ABL antibody by PLGA nanoparticles suppresses the oncogenesis of chronic myeloid leukemia cells. | [102] |
| Cops3 | Monoclonal, rabbit anti-COPS3 antibody | The COP9 signalosome subunit 3 is necessary for early embryo survival by way of a stable protein deposit in mouse oocytes | [103] |
| STIP1 | Monoclonal, mouse anti-STIP1 antibody | Intracellular targeting of STIP1 inhibits human cancer cell line growth | [104] |
| Rec8 | Monoclonal, rabbit anti-Rec8 antibody | Deprotection of centromeric cohesin at meiosis II requires APC/C activity but not kinetochore tension. | [105] |
| Pericentrin | Monoclonal, mouse anti-Pericentrin antibody | Two mechanisms drive pronuclear migration in mouse zygotes | [106] |
| RBD (SARS-COV 2) | full-length sACE2 fused to Fc | Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. | [107] |
| TDP43 | Monoclonal, E6 mouse IgG2A anti-RRM1 TDP43 antibody | Monoclonal full-length antibody against TAR DNA binding protein 43 reduces related proteinopathy in neurons. | [108] |
| Nup133, POM121, NDC1 |
Mouse anti-Nup133, Rabbit anti-Nup133, Rabbit anti-POM121, Mouse anti-NDC1, |
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. | [109] |
| CyK4 | Monoclonal, mouse anti-CYK4 antibody | Symmetry breaking in hydrodynamic forces drives meiotic spindle rotation in mammalian oocytes | [110] |
| BTG4 |
Monoclonal, rabbit anti-BTG4 antibody | Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse | [111] |
| RCC1 | Polyclonal, goat anti-RCC1 antibody | Ran GTP is essential for MI spindle assembly and function both in humans and mice | [112] |
| PKM2 | Monoclonal, rabbit anti-PKM2 antibody | Glucose metabolism distinguishes TE from ICM fate during mammalian embryogenesis | [113] |
| Tead4 |
Monoclonal, mouse anti-Tead4 antibody | A framework for TRIM21-mediated protein depletion in early mouse embryos | [114] |
| CENPF | Monoclonal, sheep anti-CENPF antibody | Loss of CENPF leads to developmental failure in mouse embryos | [115] |
| SNAP23 |
Monoclonal, mouse anti-SNAP23 antibody | SNAP23 is required for constitutive and regulated exocytosis in mouse oocytes | [116] |
| MHTT/wtHTT | Monoclonal, mouse anti-mHTT antibody | Targeting the HTT levels offer systematic, mechanism-driven routes towards curing HD | [117] |