Table 1.
Baseline characteristics of the study population stratified by development of late-life dementia.
| Whole cohort | No late-life dementia | Late-life dementia | P-value | |
|---|---|---|---|---|
| Number | 958 | 808 | 150 | |
| Age, years | 75.0 ± 2.6 | 74.8 ± 2.5 | 76.0 ± 2.8 | <0.001 |
| Body mass index, kg/m2 | 27.1 ± 4.4 | 27.3 ± 4.5 | 26.4 ± 4.0 | 0.021 |
| Ever smoked, yes (%) | 340 (35.5) | 271 (33.5) | 69 (46.0) | 0.003 |
| Systolic blood pressure, mmHg | 137.4 ± 18.0 | 137.2 ± 17.2 | 138.4 ± 22.1 | 0.463 |
| Antihypertensive medication, yes (%) | 403 (42.1) | 339 (42.0) | 64 (42.7) | 0.871 |
| Diabetes, yes (%) | 57 (5.9) | 41 (5.1) | 16 (10.7) | 0.008 |
| Estimated CVD risk (Framingham), % | 21.8 ± 10.7 | 21.4 ± 10.1 | 24.0 ± 13.5 | 0.006 |
| Statins medication, yes (%) | 182 (19.1) | 154 (19.1) | 28 (18.7) | 0.910 |
| Low dose aspirin, yes (%) | 189 (19.7) | 152 (18.8) | 37 (24.7) | 0.098 |
| Previous ASVD, yes (%) | 105 (11.0) | 88 (10.9) | 17 (11.3) | 0.873 |
| Alcohol | 0.754 | |||
| None (%) | 171 (17.8) | 141 (17.5) | 30 (20.0) | |
| <10 standard drinks p/w (%) | 631 (65.9) | 535 (66.2) | 96 (64.0) | |
| ≥10 standard drinks p/w (%) | 156 (16.3) | 132 (16.3) | 24 (16.0) | |
| Randomisation, calcium (%) | 465 (48.5) | 404 (50.0) | 61 (40.7) | 0.036 |
| APOE genotypes | <0.001 | |||
| APOEℇ2/3, yes (%) | 160 (16.7) | 145 (17.9) | 15 (10.0) | |
| APOEℇ2/4, yes (%) | 18 (1.9) | 16 (2.0) | 2 (1.3) | |
| APOEℇ3/3, yes (%) | 581 (60.6) | 496 (61.4) | 85 (56.7) | |
| APOEℇ3/4, yes (%) | 186 (19.4) | 146 (18.1) | 40 (26.7) | |
| APOEℇ4/4, yes (%) | 13 (1.4) | 5 (0.6) | 8 (5.3) | |
| Abdominal aortic calcification | <0.001 | |||
| Low (AAC24 0 or 1) | 428 (44.7) | 384 (47.5) | 44 (29.3) | |
| Moderate (AAC24 2–5) | 349 (36.4) | 277 (34.3) | 72 (48.0) | |
| Extensive (AAC24 ≥6) | 181 (18.9) | 147 (18.2) | 34 (22.7) |
Data expressed as mean ± SD or number and (%). Abbreviations: mmHg, millimetres mercury; ASVD, atherosclerotic vascular disease; APOE, apolipoprotein E. P-values obtained using ANOVA or Chi Square test where appropriate.