TABLE 5.
Hazard ratios of myocardial infarction, ischemic stroke, and hemorrhagic stroke types by tertiles of drinking water magnesium exposure in 26,733 women of the Swedish Mammography Cohort
| HR (95% CI) | ||||
|---|---|---|---|---|
| Tertiles of magnesium concentration in tap water (mg/L), range (p50) | Cases, n | Person-years, n | Age-adjusted model1 | Multivariable adjusted model2 |
| Myocardial infarction | ||||
| 0.6–4.5 (4.5) | 823 | 186,852 | 1.00 | 1.00 |
| 4.6–10.5 (7.1) | 680 | 134,219 | 1.16 (1.05, 1.29) | 1.14 (1.02, 1.26) |
| 10.6–13.8 (12.7) | 520 | 134,294 | 0.86 (0.77, 0.96) | 0.91 (0.70, 1.20) |
| Ischemic stroke | ||||
| 0.6–4.5 (4.5) | 973 | 186,080 | 1.00 | 1.00 |
| 4.6–10.5 (7.1) | 741 | 134,175 | 1.06 (0.97, 1.17) | 1.07 (0.96, 1.18) |
| 10.6–13.8 (12.7) | 565 | 134,083 | 0.78 (0.70, 0.86) | 0.69 (0.54, 0.88) |
| Hemorrhagic stroke | ||||
| 0.6–4.5 (4.5) | 201 | 190,503 | 1.00 | 1.00 |
| 4.6–10.5 (7.1) | 137 | 137,303 | 0.95 (0.76, 1.18) | 0.99 (0.79, 1.24) |
| 10.6–13.8 (12.7) | 114 | 136,544 | 0.78 (0.62, 0.99) | 0.75 (0.43, 1.31) |
Adjusted for age (as time scale).
Further adjusted for age (as time scale), level of education (<9, 9, 10–11, 11–12, >12 y), household income (quartiles), smoking status (never, former <10 cigarettes/d, former ≥10 cigarettes/d, current <10 cigarettes/d, current ≥10 cigarettes/d), BMI (<20, 20–24.9, 25–29.9, and 30 kg/cm2), high cholesterol (yes/no), diabetes (yes/no), family history of cardiovascular disease (yes/no), physical activity (walk or bike ≥40 min/wk: yes/no; exercise ≥1 h/wk: yes/no), alcohol intake (never drinker, former drinker, current drinker <3 glasses/wk, current drinker 3–7 glasses/wk, current drinker >7 glasses/wk), and calcium in drinking water (tertiles).