TABLE 6.
Hazard ratios of myocardial infarction and stroke by tertiles of drinking water magnesium exposure in 13,207 women with dietary magnesium intake below the median (318 mg/d)
| HR (95% CI) | ||||
|---|---|---|---|---|
| Tertiles of magnesium concentration in tap water (mg/L), range (p50) | Number of participants (cases) | Person-years, n | Age-adjusted model1 | Multivariable-adjusted model2 |
| Myocardial infarction | ||||
| 0.6–4.5 (4.5) | 5453 (416) | 92,028 | 1.00 | 1.00 |
| 4.6–10.5 (7.1) | 3966 (356) | 66,481 | 1.22 (1.06, 1.40) | 1.21 (1.04, 1.40) |
| 10.6–13.8 (12.7) | 3788 (248) | 64,947 | 0.85 (0.73, 1.00) | 0.80 (0.55, 1.15) |
| Ischemic stroke | ||||
| 0.6–4.5 (4.5) | 5453 (499) | 91,724 | 1.00 | 1.00 |
| 4.6–10.5 (7.1) | 3966 (371) | 66,454 | 1.05 (0.92, 1.21) | 1.10 (0.95, 1.26) |
| 10.6–13.8 (12.7) | 3788 (279) | 64,826 | 0.79 (0.68, 0.91) | 0.64 (0.46, 0.89) |
| Hemorrhagic stroke | ||||
| 0.6–4.5 (4.5) | 5453 (95) | 93,970 | 1.00 | 1.00 |
| 4.6–10.5 (7.1) | 3966 (75) | 68,042 | 1.11 (0.82, 1.50) | 1.13 (0.82, 1.56) |
| 10.6–13.8 (12.7) | 3788 (50) | 66,120 | 0.75 (0.75, 1.06) | 0.85 (0.85, 2.03) |
Adjusted for age (as time scale).
Further adjusted for age (as time scale), level of education (< 9, 9, 10–11, 11–12, >12 y), household income (quartiles), smoking status (never, former <10 cigarettes/d, former ≥10 cigarettes/d, current <10 cigarettes/d, current ≥10 cigarettes/d), BMI (<20, 20–24.9, 25–29.9, and 30 kg/cm2), high cholesterol (yes/no), diabetes (yes/no), family history of cardiovascular disease (yes/no), physical activity (walk or bike ≥40 min/wk: yes/no; exercise ≥1 h/wk: yes/no), alcohol intake (never drinker, former drinker, current drinker <3 glasses/wk, current drinker 3–7 glasses/wk, current drinker >7 glasses/wk), and calcium in drinking water (tertiles).