Table 3.

Results of the multivariable regression of changes in cognition, ADL, and depressive symptoms on HRQoL and costs

	Increase in HRQoL utility score*		Increase in log costs*
Variable	Coefficient (S.E.)	significance	Coefficient (S.E.)	significance
Change in cognition†	0.008 (0.007)	0.277	0.054 (0.119)	0.651
Change in ADL†	–0.006 (0.001)	< 0.001	n/a‡	n/a
Change in depressive symptoms†	–0.004 (0.0004)	< 0.001	0.015 (0.006)	0.014
Age (baseline)	–0.0002 (0.0004)	0.589	0.002 (0.008)	0.749
Sex	0.004 (0.004)	0.304	–0.056 (0.069)	0.414
Education	–0.0001 (0.0006)	0.830	–0.0089 (0.0099)	0.369
Intervention allocation	–0.006 (0.004)	0.166	0.032 (0.069)	0.639

^*results of mixed linear model using change scores. Log costs were used in calculations; ^†increase in ADL score and depressive symptoms indicates worse outcome and increase in cognition and HRQoL indicates better outcome. ^‡excluded because not significant in univariable analysis. Analyses were adjusted for age, sex, education and intervention allocation.