Table 2.
A) Overview of the demographic data at baseline and follow-up of the MIBGP and the MIBGN group. B) Results of [123I]MIBG scintigraphy and [123I]FP-CIT-SPECT
| Baseline | Follow-up | Statistical Analysis | ||||||
| p < 0.05 | ||||||||
| MIBGP | MIBGN | MIBGP | MIBGN | Bl vs. Fu | MIBGP vs. | |||
| n = 29 | n = 8 | n = 27 | n = 8 | MIBGN | ||||
| MIBGP | MIBGN | Bl | Fu | |||||
| p | p | p | p | |||||
| A: Demographic data | ||||||||
| Male (%) | 26 (89.7) | 6 (75.0) | 24 (88.9) | 6 (75.0) | ||||
| Age at diagnosis (y) | 66.0 (61.0–70.5) | 58.5 (53.8–65.0) | 0.032 | |||||
| Age (y) | 66.0 (62.5–71.5) | 58.5 (53.8–65.0) | 70.0 (66.0–74.0) | 61.5 (60.3–68.3) | 0.014 | 0.020 | ||
| Fu time (mo) | 48.0 (36.0–62.0) | 46.5 (22.5–72.8) | n.s. | |||||
| Duration of RBD at diagnosis (mo) | 59.0 (25.5–102.5) | 57.0 (12.5–113.3) | n.s. | |||||
| ADT (%) | 7 (24.1) | 5 (62.5) | 7 (24.1) | 5 (62.5) | ||||
| UPDRS-III | 2 (0–3) | 3 (0–6) | 4 (2–7) | 3 (1–3) | 0.002 | n.s.* | n.s. | n.s. |
| TDI | 16.3 (9.5–21.9) | 28.6 (21.3–33.7) | 13.5 (8.0–18.3) | 30.1 (27.8–32.4) | 0.005 * | n.s.* | < 0.001 | < 0.001 |
| (T) score | 2.0 (0.0.–4.9) | 6.0 (3.8–7.4) | 0.0 (0.0–2.0) | 5.5 (4.5–7.3) | 0.002 * | n.s.* | 0.006 | < 0.001 |
| (D) score | 9.0 (6.0–10.0) | 11.0 (8.0–13.5) | 7.0 (4.0–9.0) | 11.5 (10.0–13.0) | 0.009 * | n.s.* | 0.029 | < 0.001 |
| (I) score | 5.0 (3.0–8.5) | 11.5 (9.5–13.0) | 5.0 (3.0–8.0) | 13.0 (12.3–13.8) | n.s.* | n.s.* | < 0.001 | < 0.001 |
| MOCA | 27.0 (25.3–28.8) | 26.5 (24.3–28.5) | 28.0 (27.0–29.0) | 28.5 (27.0–29.8) | 0.076 | n.s. | n.s | n.s |
| PDNMS | 7.0 (4.0–8.0) | 10.0 (6.0–13.8) | 8.0 (5.0–11.0) | 8.5 (4.8–15.5) | 0.004 | n.s. | 0.019 | 0.637 |
| PD Converter (%) | 7 (26) | 0 (0) | ||||||
| B: Results of [123I]MIBG scintigraphy and [123I]FP-CIT-SPECT | ||||||||
| MIBG value (n = 28) | 1.15 (1.10–1.26) | 1.7 (1.6–1.9) | < 0.001 | |||||
| Caudate nucleus right | 2.2 (1.7–2.5) | 2.9 (2.7–2.9) | 0.001 | |||||
| Caudate nucleus left | 2.2 (1.8–2.4) | 2.8 (2.5–3.0) | < 0.001 | |||||
| Putamen right | 1.9 (1.4–2.1) | 2.5 (2.2–2.6) | 0.001 | |||||
| Putamen left | 1.8 (1.4–2.0) | 2.5 (2.2–2.5) | < 0.0001 | |||||
Values are shown as median (IQR). Non-parametric Mann-Whitney-U-test was used to compare both subgroups. Wilcoxon-test was used to compare baseline and follow-up results within each group. *If the question was one-sided, the medians were compared. If the observed tendency corresponded to the null hypothesis, the test was evaluated as not significant.