Table 1.
Clinical characteristics of late-life major depressive disorder and bipolar disorder at hospitalization
| Diagnosis at hospitalization | Major depressive disorder | Bipolar disorder | p |
| Total | 50 | 16 (mania 5, depression 11) | |
| Sex (female) (%) | 38 (76%) | 12 (75%) | 0.588 |
| Age (range) (y) | 74.4±6.6 (65–87) | 72.3±4.7 (65–84) | 0.232 |
| Education (y) | 12.1±2.5 | 12.9±2.2 | 0.264 |
| Mean hospital stay (days) | 119.9±84.6 | 92.3±41.9 | 0.095 |
| HAMD-17 total (n) | 23.2±8.3 (n = 40) | 18.3±5.3 (n = 8) | 0.116 |
| MMSE total (n) | 22.0±5.8 (n = 33) | 25.4±4.4 (n = 10) | 0.106 |
| ECT during hospitalization (%) | 18 (36%) | 3 (18.8%) | 0.197 |
| Brain CT/MRI | 50 | 16 | |
| Brain perfusion SPECT | 33 (66%) | 8 (50%) | |
| MIBG | 31 (62%) | 6 (37.5%) | |
| DAT scan | 26 (52%) | 6 (37.5%) | |
| Mean SBR in DAT imaging | 3.7±1.5 | 4.2±0.9 | 0.499 |
| Diagnosis at discharge | |||
| Mood disorder | 33 (66%) | 14 (87.5%) | |
| Neurodegenerative diseases (including dementia) | 17 (34%) | 2 (12.5%) | 0.087 |
| Dementia | 12 (24%) | 0 | 0.026* |
| Subtypes of dementia (n) | DLB (5) | ||
| AD (3) | |||
| VaD (1) | |||
| AD+VaD (1) | |||
| iNPH 1 | |||
| Unspecified 1 | |||
| Subtypes of neurodegenerative | PD 3 | PD 2 | |
| disorders except dementia | ALS 1 | ||
| Anti-GAD antibody-positive | |||
| cerebellar ataxia 1 |
Values are expressed as mean±standard deviation. *p < 0.05. HAMD-17, 17-item Hamilton Depression Rating Scale; MMSE, Mini-Mental State Examination; ECT, electroconvulsive therapy; SPECT, single-photon emission computed tomography; MIBG, 123I-metaiodobenzylguanidine myocardial scintigraphy; DAT, dopamine transporter; SBR, specific binding ratio; DLB, dementia with Lewy bodies; AD, Alzheimer’s disease; VaD, vascular dementia; iNPH, idiopathic normal pressure hydrocephalus; PD, Parkinson’s disease; ALS, amyotrophic lateral sclerosis; GAD, glutamic acid decarboxylase.