Table II.
Baseline risk factors associated with acute hepatitis during hospital stay in 1,304 patients with COVID-19 infection (univariate and multivariate analysis).
| Univariate analysis | Multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Hazard ratio | P-value | 95% Confidence interval Lower limit | 95% Confidence interval Upper limit | Hazard ratio | P-value | 95% Confidence interval Lower limit | 95% Confidence interval Upper limit |
| Age, years | 0.99 | 0.61 | 0.97 | 1.054 | ||||
| Sex, male | 0.89 | 0.75 | 0.45 | 1.72 | ||||
| Co-morbidities | ||||||||
| Diabetes mellitus | 1.36 | 0.44 | 0.62 | 2.99 | ||||
| Severe (class II) obesity (BMI ≥35 kg/m²) | 1.42 | 0.56 | 0.43 | 4.71 | ||||
| Arterial hypertension | 1.31 | 0.47 | 0.63 | 2.68 | ||||
| Gastrointestinal symptoms | 1.97 | 0.17 | 0.74 | 5.33 | ||||
| AST (IU/l) | 1.008 | <0.001 | 1.006 | 1.009 | 1.008 | <0.001 | 1.006 | 1.011 |
| ALT (IU/l) | 1.007 | <0.001 | 1.006 | 1.009 | ||||
| ALP (IU/l) | 1.002 | 0.51 | 0.99 | 1.006 | ||||
| γ-GT (IU/l) | 1.002 | 0.19 | 0.99 | 1.005 | ||||
| Total bilirubin (mg/dl) | 0.99 | 0.34 | 0.908 | 1.095 | ||||
| LDH (IU/l) | 1.002 | <0.001 | 1.001 | 1.003 | ||||
| Albumin (g/dl) | 0.99 | 0.64 | 0.97 | 1.017 | ||||
| CRP (mg/l) | 1.00 | 0.81 | 0.99 | 1.001 | ||||
| INR | 0.98 | 0.85 | 0.85 | 1.10 | ||||
| D-Dimers (mg/dl) | 1.00 | 0.99 | 0.99 | 1.001 | ||||
| Fibrinogen (mg/dl) | 1.001 | 0.27 | 0.99 | 1.003 | ||||
| Ferritin (ng/ml) | 1.003 | 0.007 | 1.001 | 1.004 | ||||
| WBC (x109/l) | 0.99 | 0.85 | 0.93 | 1.06 | ||||
| PLTs (x109/l) | 0.99 | 0.26 | 0.99 | 1.002 | ||||
| HBsAg (+) or anti-HCV (+) | 4.05 | 0.026 | 1.18 | 13.9 | ||||
| COVID-19 medication | ||||||||
| Remdesivir | 0.41 | 0.025 | 0.19 | 0.89 | ||||
| Dexamethasone | 1.21 | 0.76 | 0.36 | 3.98 | ||||
| Tocilizumab | 1.98 | 0.09 | 0.88 | 4.47 | ||||
AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; γ-GT, γ-glutamyl transpeptidase; LDH, lactate dehydrogenase; INR, international normalized ratio; CRP, C-reactive protein; WBC, white blood count; PLTs, platelets; BMI: body mass index.