Table III.

Baseline risk factors associated with liver injury (LI) during hospital stay in 1.304 patients with COVID-19 infection (univariate and multivariate analysis).

	Univariate analysis				Multivariate analysis
Variables	Hazard ratio	P-value	95% Confidence interval Lower limit	95% Confidence interval Upper limit	Hazard ratio	P-value	95% Confidence interval Lower limit	95% Confidence interval Upper limit
Age, years	0.992	0.013	0.985	0.998
Sex, male	0.83	0.12	0.669	1.049
Co-morbidities
Diabetes mellitus	0.91	0.49	0.67	1.21
Severe (class II) obesity (BMI ≥35)	0.82	0.38	0.53	1.27
Arterial hypertension	0.87	0.24	0.68	1.11
Gastrointestinal symptoms	1.13	0.46	0.81	1.59
AST (IU/l)	1.005	<0.001	1.004	1.006	1.002	<0.001	1.001	1.003
ALT (IU/l)	1.005	<0.001	1.004	1.006
ALP (IU/l)	1.003	<0.001	1.002	1.004	1.003	<0.001	1.002	1.004
γ-GT (IU/l)	1.003	<0.001	1.002	1.004
Total bilirubin (mg/dl)	0.979	0.93	0.88	1.016
LDH (IU/l)	1.001	<0.001	1.00	1.002
Albumin (g/dl)	0.99	0.63	0.99	1.003
CRP (mg/l)	1.0	0.98	0.99	1.002
INR	0.99	0.86	0.97	1.018
D-Dimers (mg/dl)	1.001	0.015	1.0	1.002
Fibrinogen (mg/dl)	1.001	0.33	0.99	1.002
Ferritin (ng/ml)	1.01	<0.001	1.001	1.02	1.001	0.005	1.00	1.002
WBC (x109/l)	0.995	0.62	0.99	1.001
PLTs (x109/l)	1.0	0.79	0.99	1.001
HBsAg (+) or anti-HCV (+)	1.42	0.21	0.83	2.43
COVID-19 medication
Remdesivir	0.79	0.13	0.59	1.068
Dexamethasone	1.05	0.79	0.72	1.51
Tocilizumab	0.91	0.56	0.67	1.24

AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; γ-GT, γ-glutamyl transpeptidase; LDH, lactate dehydrogenase; INR, international normalized ratio; CRP, C-reactive protein; WBC, white blood count; PLTs, platelets.